河北大学化学与环境科学学院研究生导师：李振华

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河北大学化学与环境科学学院研究生导师李振华介绍如下：

一、个人简介

李振华，男，1986年10月出生于河北省遵化市，理学博士，副教授，硕士生导师，2015年1月毕业于中国科学院长春应用化学研究所，同年被引进到河北大学化学与环境科学学院工作，并于2016年晋升为硕士生导师。迄今为止发表学术论文40余篇，包括一作和通讯作者的Advanced Functional Materials, Chemical Communications, Advanced Healthcare Materials及Biomaterials等国际TOP期刊，所有文章共被引用一千三百余次，H-Index 24 (Google Scholar)。

二、联系方式

E-mail: zhenhuali@hbu.edu.cn; zhenhuali1013@163.com

邮 编：071002

地 址：河北省保定市五四东路180号

三、学习和工作经历

教育经历：

2009/9 - 2015/1，中国科学院长春应用化学研究所，无机化学专业，博士

2005/9 - 2009/6，河北大学，生物工程专业，学士

工作经历：

2017/8-至今， 北卡罗莱纳州立大学， 博士后

2015/1 - 至今，河北大学，化学与环境科学学院，副教授

四、主要研究方向

纳米医学、化学生物学、生物材料

五、科研项目

1. 国家自然科学基金项目，21601046、 靶向肿瘤乏氧区的智能载药体系的构建及其抗肿瘤作用研究、2017年1月至2019年12月、19万、在研、主持人; 2、河北省自然科学基金项目，B2015201097、多功能上转换纳米药物载体连接的间充质干细胞：新型“细胞补丁”用于肿瘤趋向的治疗、2015年01月至2017年12月、4万、在研、主持人。

六、Publications (代表性成果)

Orcid: http://orcid.org/0000-0001-9751-0864

ResearcherID: http://www.researcherid.com/rid/T-7171-2017

Corresponding-Author (通讯作者)

(1) Fei Duan, Xiaochen Feng, Xinjian Yang, Wentong Sun, Yi Jin, Huifang Liu, Kun Ge, Xing-Jie Liang, Zhenhua Li* and Jinchao Zhang*. A Simple and Powerful Co-Delivery System Based on pH-Responsive Metal-Organic Frameworks for Enhanced Cancer Immunotherapy. Biomaterials, 2017, 122, 23-

33.

(2) Huihui Ren,# Shizhu Chen,# Yanan Jin, Cuimiao Zhang, Xinjian Yang, Kun Ge, Xing-Jie Liang, Zhenhua Li* and Jinchao Zhang*. A Traceable and Bone-targeted Nanoassembly Based on Defect-related Luminescent Mesoporous Silica for Enhanced Osteogenic Differentiation. Journal of Materials

Chemistry B, 2017, 5, 1585-1593..

(3) Fei Duan,# Xiaochen Feng,# Xinjian Yang, Huifang Liu, Guoqiang Zhou, Shuxiang Wang, Zhenhua Li*, Xing-Jie Liang* and Jinchao Zhang*. Metal–Carbenicillin Frameworks Based Nanoantibiotics with Enhanced Penetration and Highly Efficient Killing Multidrug-Resistant Bacteria. Biomaterials, 2017,

144, 155-165.First Author(第一作者)

(4) Kai Dong, Zhenhua Li, Hanjun Sun, Enguo Ju, Jinsong Ren, Xiaogang Qu. Pathogen-mimicking nanocomplexes: self-stimulating oxidative stress in tumor microenvironment for chemo-immunotherapy. Materials Today. 2017, 20, 346-353. (#Co-first author)

(5) Zhenhua Li, Zhen Liu, Zhaowei Chen, Enguo Ju, Wei Li, Jinsong Ren* and Xiaogang Qu*. Bioorthogonal chemistry for selective recognition, separation and killing bacteria over mammalian cells. Chemical Communications 2016, 52, 3482-3485.

(6) Zhenhua Li, Kai Dong, Yan Zhang, Enguo Ju, Zhaowei Chen, Jinsong Ren* and Xiaogang Qu*. Biomimetic nanoassembly for targeted antigen delivery and enhanced Th1-type immune response. Chemical Communications 2015, 51, 15975-15978.

(7) Zhenhua Li, Kai Dong, Sa Huang, Enguo Ju, Zhen Liu, Meili Yin, Jinsong Ren* and Xiaogang Qu*. A smart nanoassembly for multistage targeted drug delivery and magnetic resonance imaging. Advanced Functional Materials 2014, 24, 3612-3620.

(8) Xinjian Yang#, Zhenhua Li #, Enguo Ju, Jinsong Ren* and Xiaogang Qu*. Luminescent Rare-Earth Complex Functionalized Reduced Graphene Oxide for Tracking, and Photothermal Killing Drug-Resistant Bacteria. Chemistry-A European Journal 2014, 20, 394-398. (#Co-first author)

(9) Zhenhua Li, Yu Tao, Sa Huang, Nan Gao, Jinsong Ren* and Xiaogang Qu*. Lanthanide-based hollow mesoporous nanoparticles: a novel multifunctional platform for simultaneous gene delivery and cell imaging. Chemical Communications 2013, 49 (64), 7129-7131.

(10) Zhenhua Li, Zhen Liu, Meili Yin, Xinjian Yang, Jinsong Ren* and Xiaogang Qu*. Combination Delivery of Antigens and CpG by Lanthanides-based core-shell nanoparticles for enhanced immune response and dual-mode imaging. Advanced Healthcare Materials 2013, 2, 1309-1313.

(11) Zhenhua Li, Zhen Liu, Meili Yin, Xinjian Yang, Qinghai Yuan, Jinsong Ren* and Xiaogang Qu*. Aptamer-capped multifunctional mesoporous strontium hydroxyapatite nanovehicle for cancer-cell-responsive drug delivery and imaging. Biomacromolecules, 2012, 13 (12), 4257-4263.Co-Author(共同作

者)

(12) Zhaowei Chen, Zhenhua Li, Youhui Lin, Meili Yin, Jinsong Ren* and Xiaogang Qu*. Biomineralization inspired surface engineering of nanocarriers for pH-responsive, targeted drug delivery. Biomaterials 2013, 34, 1364.

(13) Zhaowei Chen, Zhenhua Li, Youhui Lin, Meili Yin, Jinsong Ren* and Xiaogang Qu*. Bioresponsive hyaluronic Acid-capped mesoporous silica nanoparticles for targeted drug delivery. Chemistry-A European Journal 2013, 19, 1778.

(14) Zhaowei Chen, Zhenhua Li, Jiasi Wang, Enguo Ju, Li Zhou, Jinsong Ren* and Xiaogang Qu*. A Multi-synergistic Platform for Sequential Irradiation-Activated High-Performance Apoptotic Cancer Therapy. Advanced Functional Materials 2014, 24, 522.

(15) Enguo Ju, Zhenhua Li, Meng Li, Kai Dong, Jinsong Ren* and Xiaogang Qu*. Functional polypyrrole-silica composites as photothermal agents for targeted killing of bacteria. Chemical Communications 2013, 49, 9048.

(16) Youhui Lin, Zhenhua Li, Zhaowei Chen, Jinsong Ren* and Xiaogang Qu*. Mesoporous silica-encapsulated gold nanoparticles as artificial enzymes for self-activated cascade catalysis. Biomaterials 2013, 34, 2600.

(17) Li Zhou, Zhenhua Li, Enguo Ju, Zhen Liu, Jinsong Ren* and Xiaogang Qu*. Aptamer-Directed Synthesis of Multifunctional Lanthanide-Doped Porous Nanoprobes for Targeted Imaging and Drug Delivery. Small 2013, 9, 4262.

(18) Li Zhou, Zhenhua Li, Zhen Liu, Jinsong Ren* and Xiaogang Qu. Luminescent Carbon Dot-gated Nanovehicles for pH-triggered Intracellular Controlled Release and Imaging. Langmuir 2013, 29, 6396.

(19) Li Zhou, Zhenhua Li, Zhen Liu, Meili Yin, Jinsong Ren* and Xiaogang Qu*. One-step Nucleotide-programmed Growth of Porous Upconversion Nanoparticles: Application to Cell Labeling and Drug Delivery. Nanoscale 2014, 6, 1445.

(20) Yu Tao, Zhenhua Li, Enguo Ju, Jinsong Ren* and Xiaogang Qu*. Polycations-functionalized water-soluble gold nanoclusters: a potential platform for simultaneous enhanced gene delivery and cell imaging. Nanoscale 2013, 5, 6154.

(21) Yu Tao, Zhenhua Li, Enguo Ju, Jinsong Ren* and Xiaogang Qu*. One-step DNA-programmed growth of CpG conjugated silver nanoclusters: a potential platform for simultaneous enhanced immune response and cell imaging. Chemical Communications 2013, 49, 6918.

(22) Zhen Liu, Zhenhua Li, Jianhua Liu, Song Gu, Qinghai Yuan, Jinsong Ren* and Xiaogang Qu*. Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent. Biomaterials 2012, 33, 6748.

(23) Meili Yin, Zhenhua Li, Zhen Liu, Jinsong Ren,* Xinjian Yang, and Xiaogang Qu.* Photosensitizer-incorporated G-quadruplex DNA-functionalized magnetofluorescent nanoparticles for targeted magnetic resonance/fluorescence multimodal imaging and subsequent photodynamic therapy of cancer.

Chemical Communications 2012, 48, 6556.

(24) Meili Yin, Zhenhua Li, Zhen Liu, Xinjian Yang, Jinsong Ren*. Magnetic self-assembled zeolite clusters for sensitive detection and rapid removal of mercury(II). ACS Applied Materials & Interfaces 2012, 4, 431.

(25) Meili Yin, Zhenhua Li, Enguo Ju, Zhenzhen Wang, Kai Dong, Jinsong Ren* and Xiaogang Qu*. Multifunctional upconverting nanoparticles for near-infrared triggered and synergistic antibacterial resistance therapy. Chemical Communications 2014, 50, 10488-10490.

(26) Meili Yin, Zhenhua Li, Li Zhou, Kai Dong, Jinsong Ren* and Xiaogang Qu*. A multifunctional upconverting nanoparticle incorporated polycationic hydrogel for near-infrared triggered and synergistic treatment of drug-resistant bacteria. Nanotechnology 2016, 27.

(27) Enguo Ju, Zhenhua Li, Zhen Liu, Jinsong Ren* and Xiaogang Qu*. Near-Infrared Light-Triggered Drug-Delivery Vehicle for Mitochondria-Targeted Chemo-Photothermal Therapy. ACS Applied Materials & Interfaces 2014, 6, 4364.

(28) Enguo Ju, Zhenhua Li, Meng Li, Kai Dong, Jinsong Ren* and Xiaogang Qu*. Functional polypyrrole-silica composites as photothermal agents for targeted killing of bacteria. Chemical Communications 2013, 49, 9048-9050.

(29) Xinjian Yang, Zhenhua Li, Meng Li, Jinsong Ren* and Xiaogang Qu*. Fluorescent Protein Capped Mesoporous Nanoparticles for Intracellular Drug Delivery and Imaging. Chemistry-A European Journal 2013, 19, 15378-15383.

(30) Kai Dong, Zhen Liu, Zhenhua Li, Jinsong Ren* and Xiaogang Qu*. Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo. Advanced Materials 2013, 25, 4452-4458.

(31) Zhen Liu, Meng Li, Zhenhua Li, Fang Pu, Jinsong Ren* and Xiaogang Qu. Easy access to selective binding and recyclable separation of histidine-tagged proteins using Ni2+-decorated superparamagnetic nanoparticles. Nano Research 2012, 5, 450-459.

(32) Yu Tao, Enguo Ju, Zhenhua Li, Jinsong Ren* and Xiaogang Qu*. Engineered CpG-Antigen Conjugates Protected Gold Nanoclusters as Smart Self-Vaccines for Enhanced Immune Response and Cell Imaging. Advanced Functional Materials 2014, 24, 1004-1010.

(33) Zhaowei Chen, Zhen Liu, Zhenhua Li, Enguo Ju, Nan Gao, Li Zhou, Jinsong Ren* and Xiaogang Qu*. Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis. Biomaterials 2015, 39, 15-22.

(34) Xinjian Yang, Zhen Liu, Zhenhua Li, Fang Pu, Jinsong Ren* and Xiaogang Qu*. Near-Infrared-Controlled, Targeted Hydrophobic Drug-Delivery System for Synergistic Cancer Therapy. Chemistry-A European Journal 2013, 19, 10388-10394.

(35) Meili Yin, Li Wu, Zhenhua Li, Jinsong Ren* and Xiaogang Qu. Facile in situ fabrication of graphene-upconversion hybrid materials with amplified electrogenerated chemiluminescence. Nanoscale 2012, 4, 400-404.

(36) Meili Yin, Enguo Ju, Zhaowei Chen, Zhenhua Li, Jinsong Ren* and Xiaogang Qu*. Upconverting Nanoparticles with a Mesoporous TiO2 Shell for Near-Infrared-Triggered Drug Delivery and Synergistic Targeted Cancer Therapy. Chemistry-A European Journal 2014, 20, 14012-14017.

(37) Wei Li, Zhaowei Chen, Li Zhou, Zhenhua Li, Jinsong Ren* and Xiaogang Qu*. Noninvasive and Reversible Cell Adhesion and Detachment via Single-Wavelength Near-Infrared Laser Mediated Photoisomerization. Journal of the American Chemical Society 2015, 137, 8199-8205.

(38) Zhaowei Chen, Li Zhou, Wei Bing, Zhijun Zhang, Zhenhua Li, Jinsong Ren* and Xiaogang Qu*. Light Controlled Reversible Inversion of Nanophosphor-Stabilized Pickering Emulsions for Biphasic Enantioselective Biocatalysis. Journal of the American Chemical Society 2014, 136, 7498-7504.

(39) Kun Ge, Cuimiao Zhang, Wentong Sun, Huifang Liu, Yi Jin, Zhenhua Li, Xing-Jie Liang, Guang Jia* and Jinchao Zhang*. Up-Conversion Y2O3:Yb3+, Er3+ Hollow Spherical Drug Carrier with Improved Degradability for Cancer Treatment. ACS Applied Materials & Interfaces 2016, 8, 25078-25086.

(40) Xiaohong Hao, Xixue Hu, Cuimiao Zhang, Shizhu Chen, Zhenhua Li, Xinjian Yang, Huifang Liu, Guang Jia,* Dandan Liu, Kun Ge, Xing-Jie Liang,* and Jinchao Zhang.* Hybrid Mesoporous Silica-Based Drug Carrier Nanostructures with Improved Degradability by Hydroxyapatite. ACS Nano 2015, 9,

9614-9625.

(41) Wentong Sun, Yu Han, Zhenhua Li, Kun Ge,* and Jinchao Zhang.* Bone-Targeted Mesoporous Silica Nanocarrier Anchored by Zoledronate for Cancer Bone Metastasis. Langmuir 2016, 32, 9237-9244.