河北大学化学与环境科学学院研究生导师：成永强

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河北大学化学与环境科学学院刘保生研究生导师成永强介绍如下：

成永强，男，河北省定州市人，河北大学博士，教授，博士研究生导师。

研究方向：生化分析与生物传感。研究工作发表在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., ACS Appl. Mater. Interfaces, Analyst等期刊上。
获2012年教育部全国优秀博士学位论文提名奖；获2012年河北省优秀博士学位论文；获2010年河北省自然科学奖一等奖（2010ZR1002-3）；2017年河北省自然科学奖二等奖（2017ZR2001-2）。

联系方式：E-mail：yqcheng@hbu.edu.cn； yqcheng@126.com

一、主讲课程：仪器分析、仪器分析实验、分子光谱分析

二、研究内容：

1、核酸和蛋白质等生物大分子检测新方法新技术研究；

2、细胞、细菌识别、成像及杀伤新材料新方法研究。

三、主持科研项目

1. 国家自然科学基金(21475031)，DNA水凝胶-阳离子共轭聚合物杂化荧光纳米粒子的制备及其应用于肿瘤细胞成像与治疗研究，2015年-2018年；

2. 河北省自然科学基金(B2012201078)，滚环扩增RNA适配体无标记荧光成像原位检测microRNA，2012年-2014年；

3. 国家自然科学基金(21075028)，恒温扩增高通量高灵敏度荧光成像检测microRNA 的研究，2011年-2013年；

4. 教育部高等学校博士学科点基金(20091301120003)，基于滚环扩增的microRNA 原位、高通量分析，2010年-2012年；

5. 河北省自然科学基金(B2009000170)，滚环扩增共轭聚合物荧光共振能量转移高灵敏度检测核酸的研究，2009年-2011年

四、代表性论文：

1. Yongqiang Cheng,* Lijuan Dong, Jiangyan Zhang, Yaqing Zhao, and Zhengping Li,* Recent advances in microRNA detection, Analyst, 2018, 143, 1758-1774.

2. Jingxiao Tian, Jiangyan Zhang, Jiangtao Yang, Lingyun Du, Hao Geng, and Yongqiang Cheng,* Conjugated Polymers Act Synergistically with Antibiotics to Combat Bacterial Drug Resistance, ACS Appl. Mater. Interfaces, 2017, 9, 18512-18520.

3. Yacui Liu, Jiangyan Zhang*, Jingxiao Tian, Xiaofei Fan, Hao Geng, Yongqiang Cheng*, Multiplex detection of microRNAs by combining molecular beacon probes with T7 exonuclease-assisted cyclic amplification reaction, Anal. Bioanal. Chem., 2017, 409, 107-114.

4. Likun Zhao, Jiangyan Zhang,* Huiming Xu, Hao Geng, and Yongqiang Cheng*, Conjugated Polymers/DNA Hybrid Materials for Protein Inactivation, ACS Appl. Mater. Interfaces, 2016, 8, 22923−22929.

5. Yuanyuan Zhou, Jiangyan Zhang, Likun Zhao, Yingcun Li, Hui Chen, Shengliang Li, and Yongqiang Cheng*, Visual Detection of Multiplex MicroRNAs Using Cationic Conjugated Polymer Materials, ACS Appl. Mater. Interfaces, 2016, 8, 1520-1526.

6. Yingcun Li, Jiangyan Zhang,* Jingjing Zhao, Likun Zhao, Yongqiang Cheng* and Zhengping Li, A simple molecular beacon with duplex-specific nuclease amplification for detection of microRNA, Analyst, 2016, 141, 1071-1076.

7. Zheng Yuan, Yuanyuan Zhou, Shuxin Gao, Yongqiang Cheng*, and Zhengping Li*, Homogeneous and Sensitive Detection of microRNA with Ligase Chain Reaction and Lambda Exonuclease-Assisted Cationic Conjugated Polymer Biosensing, ACS Appl. Mater. Interfaces, 2014, 6, 6181-6185.

8. Yongqiang Cheng*, Jingjing Zhao, Hailian Jia, Zheng Yuan and Zhengping Li*, Ligase chain reaction coupled with rolling circle amplification for high sensitivity detection of single nucleotide polymorphisms, Analyst, 2013, 138, 2958-2963.

9. Yongqiang Cheng*, Qing Du, Liyong Wang, Hailian Jia, and Zhengping Li*, Fluorescently Cationic Conjugated Polymer as an Indicator of Ligase Chain Reaction for Sensitive and Homogeneous Detection of Single Nucleotide Polymorphism, Analytical Chemistry, 2012, 84, 3739-3744.

10. Liyong Wang, Yongqiang Cheng,* Hui Wang, Zhengping Li*, A Homogeneous Fluorescence Sensing Platform with Water-soluble Carbon Nanoparticles for Detection of MicroRNA and Nuclease Activity, Analyst, 2012, 137, 3667-3672.

11. TANG ZhiYuan, CHENG YongQiang*, DU Qing, ZHANG HongXia & LI ZhengPing*, Integration of rolling circle amplification and cationic conjugated polymer for the homogeneous detection of single nucleotide polymorphisms, Chinese Science Bulletin, 2011, 56, 3247-3252.

12. Yongqiang Cheng, Xian Zhang, Zhengping Li, Xiaoxia Jiao, Yucong Wang, and Yali Zhang, Highly Sensitive Determination of microRNA Using Target-Primed and Branched Rolling-Circle Amplification, Angew. Chem. Int. Ed., 2009, 48, 3268-3272.

13. Yongqiang Cheng, Zhengping Li, Baoan Du, and Xian Zhang, Homogeneous and label-free bioluminescence detection of single nucleotide polymorphism with rolling circle amplification, Analyst, 2008, 133, 750-752.

14. Yongqiang Cheng, Zhengping Li, Xian Zhang, Baoan Du, Yongshan Fan, Homogeneous and label-free fluorescence detection of single-nucleotide polymorphism using target-primed branched rolling circle amplification, Anal. Biochem., 2008, 378，123-126.

15. Yongqiang Cheng, Zhengping Li, Yuqin Su, Yongshan Fan, Ferric nanoparticle-based resonance light scattering determination of DNA at nanogram levels, Talanta, 2007, 71, 1757-1761.