重庆大学生物工程学院硕士生导师：李惠林

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重庆大学生物工程学院硕士生导师李惠林资料如下：

王亚洲，男，中美联合培养博士，重庆大学生物工程学院教授，博导、院长助理。

基本信息：

出生年月:1979年09月

籍贯：湖南常德

职称职务：教授、博士生导师；院长助理

社会兼职：中国生物材料学会会员，中国病理生理学会会员，中国生物医学工程学会会员、中国生物医学工程康复工程专业委员会青年委员

通信地址：重庆市沙坪坝区沙正街174号生物工程学院

邮政编码：400044邮箱：yazhou_wang@cqu.edu.cn

教育与工作经历：

1998.09-2002.07湘潭大学化学化工学院食品科学与工程专业学士

2002.09-2004.12重庆大学生物工程学院药物化学专业硕士

2005.03-2009.12重庆大学生物工程学院生物医学工程专业博士

2007.05-2008.08美国密苏里大学哥伦比亚分校工程学院中美联合培养博士

2009.12-2012.09重庆大学生物工程学院讲师

2012.09-2017.09重庆大学生物工程学院副教授

2017.09-至今重庆大学生物工程学院教授

其中：

2013.06-2014.06挂职重庆大学研究生院院长助理

2017.01-2017.07英国纽卡斯尔大学访问学者（生物力学研究领域）

2015.09-至今生物工程学院院长助理

研究兴趣与方向：

1.新型纳/微药物递送系统（特别是针对透血脑屏障给药）；

2.生物材料的功能化改性及其在心血管领域的应用（特别是血管内支架等植介入材料）；

3.生物力学（特别是出血性脑卒中的生物力学问题）。

近年来以第一作者或通讯作者近年来发表的主要论文（*）

[1]Dan Zou, Wei Wang, Daoxi Lei, Ying Yin, Peng Ren, Jinju Chen, Tieying Yin, Bochu Wang, Guixue Wang,Yazhou Wang*.Penetrate blood-brain barrier and enable anti-tumor and nerve repair in glioma by DOX-loaded monosialoganglioside micelles system.International Journal of Nanomedicine2017, 12:4879-4889

[2]Sun W, Huang Y, Yin T*, Wang J, Du R, Qiu J, Zhang Y,Wang Y*, Chen J, Wang G. Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site.Biomaterials Science2017, 5(6), 1144-1155.

[3]Yazhou Wang, Guixue Wang*.Polymeric nanomicelles: a potential hazard for the cardiovascular system? Nanomedicine,2017, 12(12): 1355-1358 (Editorial article)

[4] Fei Fang, Dan Zou, Wei Wang, Ying yin, Tieying Yin, Shilei Hao, Bochu Wang, Guixue Wang,Yazhou Wang*. Non-invasive Approaches for Drug Delivery to the Brain Based on the Receptor Mediated Transport,Materials Science and Engineering C, 2017(76):1316-1327

[5]Yazhou Wang*, Wei Wang, Zong Li, Shilei Hao & Bochu Wang, A novel perspective on neuron study: damaging and promoting effects in different neurons induced by mechanical stress,Biomech Model Mechanobiol, 2016;15(5):1019-27

[6]Yazhou Wang*, Zong Li, Pengyu Shao, Shilei Hao, Wei Wang, Qian Yang, Bochu Wang，A novel multiple drug release system in vitro based on adjusting swelling core of emulsion electrospun nanofibers with core–sheath structure,Materials Science and Engineering C,2014(44):109–116.

[7]Yazhou Wang* , Yiqiong Zhang, Bochu Wang, Yang Cao, Qingsong Yu, Tieying Yin, Fabrication of core–shell micro/nanoparticles for programmable dual drug release by emulsion electrospraying,J Nanopart Res,(2013) 15:1726

[8]Yazhou Wang*, Yiqiong Zhang, Pengyu Shao, Bochu Wang, Core-shell micro/nanoparticles containing multiple drugs fabricated by emulsion electrospraying,Journal of Controlled Release, 2013:172(1):e85–e86 (Abstract)

[9]Yazhou Wang, Guixue Wang, Liang Chen, Hao Li, Tieying Yin, Bochu Wang, James C-M Lee, Qingsong Yu. Electrospun nanofiber meshes with tailored architectures and patterns as potential tissue-engineering scaffolds,Biofabrication,2009 (1): 015001

[10]Yazhou Wang, Bochu Wang, Weili Qiao, Tieying Yin, A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles,Journal of Pharmaceutical Sciences, 2010.99(12):4805-4811

[11]Yazhou Wang, Bochu Wang, Guixue Wang, Tieying Yin, Qingsong Yu, A novel method for preparing electrospun fibers with nano-/micro-scale porous structures,Polymer Bulletin, 2009(63):259–265

[12]Yazhou Wang, Hao Li, Guixue Wang, Tieying Yin, Bochu Wang, Qingsong Yu, Electrospinning of polymer
nanofibers with ordered patterns and architectures.J. Nanosci. Nanotechnol.10, 1699-1706 (2010)

[13]Yazhou Wang, Weili Qiao, Bochu wang, Yiqiong Zhang, Pengyu Shao, and Tieying Yin Electrospun composite nanofibers containing nanoparticles for programmable release of dual drugs,Polymer Journal, 2011.43(5): 478-483

[14] Cao, Yang, Wang, Bochu,Wang, Yazhou, Lou, Deshuai, Polymer-controlled core-shell nanoparticles: a novel strategy for sequential drug release, RSC Advances, 2014, 4(57):30430-30439.

[15] Cao, Yang; Wang, Bochu;Wang, Yazhou; Lou, Deshuai, Dual Drug Release from Core-Shell Nanoparticles with Distinct Release Profiles, Journal of Pharmaceutical Sciences, 2014 ,103(10):3205-3216.

[16]Hao S, Wang B,Wang Y.Porous hydrophilic core/hydrophobic shell nanoparticles for particle size and drug release control [J]. Materials Science and Engineering: C, 2015. doi:10.1016/j.msec.2014.12.029

[17]Hao S, Wang B,Wang Y.Researching the dose ratio in a controlled release multiple-drug delivery system: using combination therapy with porous microparticles for the treatment of Helicobacter pylori infection [J]. Journal of Materials Chemistry B, 2015, 3(3): 417-431.

[18]Hao S,Wang Y,Wang B. Sinking-Magnetic Microparticles Prepared by the Electrospray Method for Enhanced Gastric Antimicrobial Delivery [J]. Molecular pharmaceutics, 2014, 11(5): 1640-1650.

[19]Hao S,Wang Y,Wang B, et al. Formulation of porous poly (lactic-co-glycolic acid) microparticles by electrospray deposition method for controlled drug release [J]. Materials Science and Engineering: C, 2014, 39: 113-119.

[20]Hao S, Wang B,Wang Y, et al. Enteric-coated sustained-release nanoparticles by coaxial electrospray: preparation, characterization, and in vitro evaluation [J]. Journal of nanoparticle research, 2014, 16(2): 1-11.

[21]Hao S,Wang Y, Wang B, et al. A novel gastroretentive porous microparticle for anti- Helicobacter pylori therapy: Preparation,in vitro and in vivoevaluation[J]. International journal of pharmaceutics, 2014, 463(1): 10-21.

[22]Shilei Hao,Yazhou Wang, Bochu Wang, Jia Deng, Xi Liu, Junyu Liu, Rapid preparation of pH-sensitive polymeric nanoparticle with high loading capacity using electrospray for oral drug delivery, Materials Science and Engineering C DOI:10.1016/j.msec.2013.07.009

[23]Lin Zhang,Yazhou Wang, Yang Cao, Deshuai Lou, Bochu Wang, Transport barriers and strategies of anti-tumor nanocarriers delivery system, Journal of Biomedical Materials Research: Part A 2013 DOI: 10.1002/jbm.a.34635

[24]Shilei Hao, Bochu Wang,Yazhou Wang,Liancai Zhu, Bin Wang, Tingwang Guo, Preparation of Eudragit L 100-55 enteric nanoparticles by a novel emulsion diffusion method, Colloids and Surfaces B: Biointerfaces 108 (2013) 127– 133

[25]Deshuai Lou, Bochu Wang,Yazhou Wang, Yang Cao,Selective killing of cancer stem cells by a novel dual-targeting strategy,Medical Hypotheses 79 (2012) 430–432

[26]Wang B, Liu J, Ma LN, Xiao HL,Wang YZ, Li Y, Wang Z, Fan L, Lan C, Yang M, Hu L, Wei Y, Bian XW, Chen D, Wang J.Chimeric 5/35 adenovirus-mediated Dickkopf-1 overexpression suppressed tumorigenicity of CD44?gastric cancer cells via attenuating Wnt signaling.J Gastroenterol. 2013 Jul;48(7):798-808.

主持或参与的主要科研项目情况：

[1]国家重点基础研究计划（“973”）项目：“脑出血后血肿应力对豆纹动脉神经复合体结构与功能的影响及其机制研究（2014CB541603，子课题负责人）

[2]国家自然科学基金青年基金 基于肿瘤干细胞的始动性与可塑性构建时序性联合给药微纳体系及其抗肿瘤效应的研究（31200713；2013-2015年）；项目负责人；

[3]重庆市自然科学基金 主动靶向肿瘤干细胞（CSCs）的联合给药微纳粒构建与抗肿瘤效应研究（cstc2012jjA0549；2012-2015年）；项目负责人；

[4]教育部高等学校博士学科点科研基金(20120191120058；2013-2015年)项目负责人

[5]中央高校基本科研业务费重点项目基于脑重大疾病异常微环境下神经组织损伤机制与修复研究(2015CDJZR；2015-2017年)；项目负责人；

[6]国家科技支撑计划 新型药物缓释冠脉支架（2012BAI18B02；2012-2015年）；项目研究骨干（排名第三）;

奖励与荣誉：

2010年度重庆大学 优秀博士论文

2011年度重庆市 优秀博士论文

201年重庆大学黄尚廉院士创新奖教金获得者

2014、2015、2016年度重庆大学优秀工作者

热忱欢迎药学，化学，生物学，力学，材料科学和医学等相关学科、专业并对新药、生物材料与生物医学工程领域感兴趣的本科生、硕士研究生报考研究生，也欢迎有类似背景的优秀本科生进实验室学习。