西安交通大学

 Dr. Bo LEI (雷波)

Professor, Group Leader (教授、研究小组主任）

Nanoscale Hybrid Biomaterials and Tissue Regeneration group(纳米复合生物材料与组织再生研究小组）

Group website: http://gr.xjtu.edu.cn/web/rayboo

Contacts:  rayboo@xjtu.edu.cn, 029-83395361

个人简介：主要研究方向为新型纳米生物活性材料、可吸收高分子纳米复合医用材料合成（颗粒/薄膜/水凝胶/多孔支架）、功能化（荧光/电活性/磁性/抗菌/细胞介导）、生物医学应用研究（组织修复再生、组织工程、基因细胞药物载体、细胞影像、癌症诊断治疗），2010年于华南理工大学获生物医用材料方向工学博士学位，曾为国家人体组织功能重建工程技术研究中心助理研究员、韩国高丽大学研究教授 (Research Professor, Korea University, Korea)。与美国密西根大学（University of Michigan，USA)、首尔国立大学(SNU, Korea)、日本国立物质材料所（NIMS，Japan)、德国埃朗根-纽伦堡大学 (FAU, Germany) 有广泛的科研协作联系。主要主持和参与国家自然科学基金重点项目1项，国家自然科学基金面上项目1项，参与韩国国家卫生部、国家基金项目各1项。近五年发表各种SCI学术论文20篇，其中以第一作者/通讯作者身份在J. Mater. Chem, J. Biomed. Mater. Res Part A, J. Biomed. Mater. Res. Part B, J. Am. Ceram. Soc. 等国际一流生物材料期刊发表科研论文23篇，申请受理韩国发明专利3项。
欢迎具有材料、化学、生物、医学等专业背景的同学报考CBERM中心硕士、博士研究生！！

Research Interests(研究方向)：

（1）Fabrication and properties of novel nanoscale bioactive biomaterials 新型纳米生物活性医用材料的合成与性能研究（纳米晶/纳米粒/纳米多孔支架）。

（2）Synthesis and properties of Biodegradable polymer nanohybrids (nanocomposites)可吸收高分子纳米复合医用材料合成与性能研究（纳米粒/薄膜/水凝胶/多孔支架）。

（3）Bio-functionalization of nano-biomaterials and polymer hybrids 纳米生物材料与高分子复合材料生物功能化研究（荧光/电活性/磁性/抗菌/细胞介导）

（4）Biomedical applications of nanoscale biomaterials and polymer nanohybrids 纳米生物材料与高分子复合材料生物医学应用研究（组织再生与工程、基因细胞药物载体、细胞影像、癌症诊断治疗）

Research ID: http://www.researcherid.com/rid/B-9463-2009

Research Interests (研究内容)： 

● Biomimetic, biodegradable and bioactive polymer-silicate based hybrid biomaterials for bone tissue

regeneration and tissue engineering applications

● Biomimetic and bioabsorbable polymer-based hybrid biomaterials for skin and vascular tissue

regeneration and tissue engineering applications

● Smart and biomimetic drug/protein delivery system design and biomedical applications

● Biocompatibility (blood, tissue, cells) studies and evaluation for biomimetic hybrid biomaterials.

Representative Publications (代表性论文)： 

1. Lei B, Chen X, Han X. Versatile fabrication of nanoscale sol-gel bioactive glass particles for highly efficient tissue regeneration. J. Mater. Chem, 2012, 22(33), 16906-16913 (IF=5.96). Link: http://pubs.rsc.org/en/content/articlepdf/2012/jm/c2jm31384g

2.Nanofibrous gelatin-silica hybrids scaffolds mimicking the native extracellular matrix (ECM) using thermally induced phase separation. J.Mater. Chem, 2012,  22(28), 14133-14140 (IF=5.96). Link: http://pubs.rsc.org/en/content/articlepdf/2012/jm/c2jm31290e

3. Lei B, Chen X, Han X, Li Z. Unique physical-chemical, apatite-forming properties and human marrow mesenchymal stem cells (HMSCs) response of sol-gel bioactive glass microspheres. J. Mater. Chem,  2011, 21 (34)12725-12734 (IF=5.96). Link: http://pubs.rsc.org/en/content/articlehtml/2011/jm/c1jm11547b

4. Lei B, Shin K H, Koh Y H, Kim H E. Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly(ε-caprolactone) polymer for bone tissue

regeneration. J. Biomed. Mater. Res. Part B, 2012, 100(4):967-975 (IF=2.22).

Link: http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.32659/full

5. Lei B, Shin K H, Moon Y W, Noh D Y, Koh Y H, Jin Y H, Kim H E. Synthesis and bioactivity of sol-gel derived porous, bioactive glass microspheres using chitosan as novel biomolecular template. Journal of American Ceramic Society, 2012; 95(1):30-33 (IF=2.27). Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1551-2916.2011.04918.x/full

6. Lei B, Chen X, Wang Y, Zhao N, Du C, Fang L. Surface nanoscale patterning of bioactive glass to support cellular growth and differentiation. J. Biomed. Mater. Res. Part A, 2010, 9 (4),1091-1099 (IF=3.04).  Link: http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.32776/full

7. Lei B, Chen X, Wang Y, Zhao N. Synthesis and in vitro bioactivity of novel mesoporous hollow bioactive glass microspheres. Materials Letters, 2009, 63(20)1719 (IF=2.30). Link: http://dx.doi.org/10.1016/j.matlet.2009.04.041

8. Lei B, Chen X, Wang Y, Zhao N, Miao G. Fabrication of porous bioactive glass particles by one step sintering. Materials Letters, 2010, 64(21): 2293-2295 (IF=2.30)   Link: http://dx.doi.org/10.1016/j.matlet.2010.07.066

9. Lei B, Chen X, Wang Y, Zhao N, Du C, Fang L. Influence of sintering temperature on the pore structure and apatite formation of a sol-gel derived bioactive glass. Journal of the American Ceramic Society, 2010.93 (1) 32-35 (IF=2.27). Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1551-2916.2009.03358.x/full