北京市结核病胸部肿瘤研究所

内科学

王敬慧，女，北京胸科医院肿瘤二科主任医师，医学博士，副教授，硕士研究

生导师，肿瘤研究中心副主任。

长期从事肺癌等胸部肿瘤的临床、科研和教学工作，对胸部肿瘤的诊治具有丰富的临床经验。主要研究方向为肺癌免疫及肺癌个体化治疗。共计发表论文80余篇，以第一或通讯作者在NatCommu、LungCancer等中外杂志上发表论文30余篇，并在ASCO、WCLC等会议上做壁报交流及口头发言。曾获北京市卫生局十百千“百”层次人才资助。获批第三届通州两高人才。指导或协助培养硕士及博士研究生10余名。

代表作：

1.Nong J, Gong Y, Guan Y, Yi X, Yi Y, Chang L, Yang L, Lv J, Guo Z, Jia H, Chu Y, Liu T, Chen M, Byers L, Roarty E, Lam VK, Papadimitrakopoulou VA, Wistuba I, Heymach JV, Glisson B, Liao Z, Lee JJ, Futreal PA, Zhang S, Xia X, Zhang J, Wang J. Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer. Nat Commun. 2018 Aug 6;9(1):3114. doi: 10.1038/s41467-018-05327-w. Erratum in: Nat Commun. 2019 Jan 29;10(1):552. PMID: 30082701; PMCID: PMC6079068.

2.Ma L, Li H, Wang D, Hu Y, Yu M, Zhang Q, Qin N, Zhang X, Li X, Zhang H, Wu Y, Lv J, Yang X, Yu R, Zhang S, Wang J. Dynamic cfDNA Analysis by NGS in EGFR T790M-Positive Advanced NSCLC Patients Failed to the First-Generation EGFR-TKIs. Front Oncol. 2021 Mar 25;11:643199. doi: 10.3389/fonc.2021.643199. PMID: 33842353; PMCID: PMC8030263.

3.Song H, Liu B, Dong B, Xu J, Zhou H, Na S, Liu Y, Pan Y, Chen F, Li L, Wang J. Exosome-Based Delivery of Natural Products in Cancer Therapy. Front Cell Dev Biol. 2021 Mar 2;9:650426. doi: 10.3389/fcell.2021.650426. PMID: 33738290; PMCID: PMC7960777.

4.Liu B, Wang Z, Gu M, Zhao C, Ma T, Wang J. GEO Data Mining Identifies OLR1 as a Potential Biomarker in NSCLC Immunotherapy. Front Oncol. 2021 Apr 20;11:629333. doi: 10.3389/fonc.2021.629333. PMID: 33959497; PMCID: PMC8095246.

5.Zhang X, Lv J, Wu Y, Qin N, Ma L, Li X, Nong J, Zhang H, Zhang Q, Yang X, Shi H, Wang J, Zhang S. HER2 Exon 20 Insertion Mutations in Lung Adenocarcinoma: Case Series and Response to Pyrotinib. Front Oncol. 2020 Jul 31;10:1162. doi: 10.3389/fonc.2020.01162. PMID: 32850330; PMCID: PMC7411254.