华中农业大学

华中农业大学信息学院生物信息系研究生导师龚静介绍如下：

龚静，女，博士，教授，华中农业大学，信息学院，研究员，博士生导师

邮箱：gong.jing@mail.hzau.edu.cn

工作单位

华中农业大学信息学院

研究方向

遗传变异的功能预测和实验验证。系统分析了人类中遗传变异对miRNA、lncRNA、甲基化、基因表达、可变剪切等功能的影响。构建了一系列遗传变异相关的数据库（miRNASNP、lncRNASNP、PancanQTL、Pancan-meQTL、SplicingQTL）。并结合分子流行病学、分子生物学等技术鉴定及验证了多个癌症相关的易感位点及基因。

生物大数据的整合分析及挖掘。高通量测序数据分析及TCGA、ENCODE、GTEx等大型数据库资源的整合分析。

教育经历

2003.09-2008.06 华中科技大学，预防医学系，医学学士

2008.09-2013.06 华中科技大学，生物信息学系，工学博士

主要职历

2013.07-2015.06 华中科技大学，公共卫生学院，博士后

2015.07-2017.12 华中科技大学，公共卫生学院，讲师

2018.01-2018.09 华中科技大学，公共卫生学院，副教授，硕士生导师

2016.04-2018.04 美国，德克萨斯大学休斯顿健康科学中心(UThealth)，访问学者

2018.09-至今 华中农业大学，信息学院，研究员，博士生导师

科研成果

主要致力于生物大数据的整合分析和肿瘤相关的分子流行病学研究。主持国家自然科学青年基金、中国博士后基金等课题。以第一作者或通讯作者在Annals of oncology、Nucleic Acids Research（4篇）、Cell Reports、Carcinogenesis、European journal of cancer等杂志上发表SCI 文章20多篇，累计影响因子超过100分，其中2篇论文被评为ESI高被引论文，1篇引用次数达250次。

代表性论文：

1. Gong, J.*, Wan, H., Mei, S., Ruan, H., Zhang, Z., Liu, C., Guo, A.Y., Diao, L., Miao, X. and Han, L. (2018) Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer. Nucleic Acids Res. (IF:10.2)

2. Gong, J.,Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. (2018) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with a MYC regulated SNP rs6983267. Annals of oncology. 29(3), 632-639. (IF: 11.8)

3. Gong, J., Li, Y., Liu, C.J., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D.H., Park, P.K., Diao, L., Putkey, J.A., Yang, L., Guo, A.Y., Lin, C. and Han, L. (2017) A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell reports, 21, 1968-1981. (IF: 8.3, 2017.11.14 Volume 21, Issue 7, 封面文章)

4. Gong, J., Mei, S., Liu, C., Xiang, Y., Ye, Y., Zhang, Z., Feng, J., Liu, R., Diao, L., Guo, A.Y., Miao, X., and Han, L. (2018) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, Nucleic Acids Research. 46, D971-D976. (IF:10.2)

5. Gong, J., Liu, C., Liu, W., Xiang, Y., Diao, L., Guo, A.Y. and Han, L. (2017) LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids research, 45, D79-D84. (IF:10.2)

6. Gong, J., Liu, W., Zhang, J., Miao, X. and Guo, A.Y. (2015) lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse. Nucleic acids research, 43, D181-186. (IF:10.2, 引用70次，ESI高被引论文)

7. Gong, J., Tong, Y., Zhang, H.M., Wang, K., Hu, T., Shan, G., Sun, J. and Guo, A.Y. (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human mutation, 33, 254-263. (IF:4.6, 引用255次)

8. Zou, D., Lou, J., Ke, J., Mei, S., Li, J., Gong, Y., Yang, Y., Zhong, R., Chang, J.,Gong, J.,* and Miao, X.* (2018) Integrative eQTL-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European journal of cancer. 93, 1-9. (IF:6.0)

9. Ke, J., Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Gong, J*. (2017) Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer. Molecular carcinogenesis, 56, 2014-2021. (IF:4.2)

10. Gong, J., Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Miao, X. (2016) A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis, 37, 443-451. (IF:5.1, ESI高被引论文)

11. Ke, J., Lou, J., Zhong, R., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Chang, J. and Gong, J.* (2016) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population. Scientific reports, 6, 25194. (IF:4.3)

12. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Tian, J., Chang, J., Zhong, R., Gong, J.* and Miao, X.* (2016) Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1. Oncotarget, 7, 35199-35207. (IF:5.2)

13. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y. and Gong, J.* (2015) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PloS one, 10, e0138478. (IF:2.8)

14. Gong, J., Liu, C., Liu, W., Wu, Y., Ma, Z., Chen, H. and Guo, A.Y. (2015) An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. Database : the journal of biological databases and curation, 2015, bav029. (IF:3.3)

15. Xia, X., Chen, W., Li, J., Chen, X., Rui, R., Liu, C., Sun, Y., Liu, L., Gong, J.* and Yuan, P*. (2014) Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies. Scientific reports, 4, 7480. (IF:4.3)

16. Gong, J., Wu, Y., Zhang, X., Liao, Y., Sibanda, V.L., Liu, W. and Guo, A.Y. (2014) Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing. RNA biology, 11, 1375-1385. (IF:3.9)

17. Gong, J., Shen, N., Zhang, H.M., Zhong, R., Chen, W., Miao, X., and Guo, A.Y. (2014). A genetic variant in microRNA target site of TGF-beta signaling pathway increases the risk of colorectal cancer in a Chinese population. Tumour biology, 35, 4301-4306. (IF:3.7)

18. Hong, Y., Chen, X.Q., Li, J.Y., Liu, C., Shen, N., Zhu, B.B., Gong, J.,* and Chen, W.* (2014). Current evidence on the association between rs3757318 of C6orf97 and breast cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 15, 8051-8055.

19. Liu, D.＃, Gong, J.#, Dai, W., Kang, X., Huang, Z., Zhang, H.M., Liu, W., Liu, L., Ma, J., Xia, Z., Chen, Y., Chen, Y., Wang, D., Ni, P., Guo, A.Y. and Xiong, X. (2012) The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation. PloS one, 7, e36146. (IF:2.8)

20. 龚静, 柳纯洁, 缪小平, 郭安源. 人类长链非编码RNA 相关SNP 鉴定与功能预测的研究进展[J].生物技术通报,2015,11:1-8.

欢迎对生物信息学感兴趣的博士后、研究生和本科生加入我们的研究小组！