华东理工大学

华东理工大学生物工程学院生物工程研究生导师谢静莉介绍如下：

食品科学专业：硕士生导师

生物工程专业：硕士生导师

生物工程领域：工程硕士导师

谢静莉，女，工学博士，副研究员，华东理工大学生物工程学院。

现任生物反应器工程国家重点实验室常务副主任，曾任华东理工大学生物工程学院食品科学与工程系副主任、常务副主任。先后作为课题组长或负责人承担科技部863计划、国家自然科学基金青年基金项目、上海市科技攻关项目子课题，科技部973计划项目子课题等多项国家及省部级课题，并与雀巢上海研发有限公司、美国派拉蒙农场有限公司、上海汉康豆类食品有限公司等多家国内外企业进行合作。发表学术论文53篇，其中以通讯/第一作者身份发表SCI论文30篇，授权专利7项。

主要经历：

2005年4月至今：华东理工大学生物工程学院食品科学与工程系教师，生物反应器工程国家重点实验室固定人员

2003年10月-2005年3月于西班牙：CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS（最高科学理事会）CENTRO DE INVESTIGACIONES BIOLOGICAS （生物研究中心），分子生物学博士后研究工作

2003年6月毕业于华东理工大学生物工程学院生物反应器工程国家重点实验室，工学博士

2000年7月毕业于华东理工大学生物工程学院生物反应器工程国家重点实验室，工学硕士

1996年7月毕业于华东理工大学能源化工系，工学学士

主要研究方向：

食品生物技术：基于功能基因组学的乳酸菌益生功能研究与天然活性物质代谢途径研究；基于结构生物学的食品酶学研究与酶制剂开发；具有益生和促进健康作用的发酵食品开发技术。

功能性食品：基于生物信息学与生物计算学的食源性活性肽靶向酶解与构效关系研究；活性肽类功能食品开发技术。

主讲课程：

食品科学硕士点专业主干课程：食品生物技术与工程

食品科学与工程系本科课程：专业英语、分子营养学

论文及专利（2014-2017）：

论文
1.Guo M#, Chen X#, Wu J, Zhang L, Huang W, Yuan Y, Fang M, Xie J*, Wei D. Angiotensin I-converting enzyme inhibitory peptides from Sipuncula (Phascolosoma esculenta). Process Biochemistry. 2017, DOI 10.1016/j.procbio.2017.08.009

2.Zhu Q, Chen X, Wu J,Zhou Y, Qian Y, Fang M, Xie J*, Wei D. Dipeptidyl peptidase IV Inhibitory peptides from Chlorella vulgaris: In silico gastrointestinal hydrolysis and molecular mechanism. European Food Research and Technology. 2017, DOI 10.1007/s00217-017-2879-1

3.Zhang J, Zhao L, Gao B, Wei W, Wang H, Xie J*. Protopectinase production by Paenibacillus polymyxa Z6 and its application in pectin extraction from apple pomace. Journal of Food Processing and Preservation. 2017(1): e13367

4.Yang Y, Sun J, Wu J, Zhang L, Du L, Matsukawa S, Xie J*, Wei D. Characterization of a novel α-L-arabinofuranosidase from Ruminococcus albus 7 and rational design for its thermostability. Journal of Agricultural and Food Chemistry. 2016 Dec, 64 (40): 7546–7554

5.Lang C, Yang R, Yang Y, Zhao L, Gao B, Wei W, Wang H, Matsukawa S, Xie J*, Wei D. An acid-adapted endo-a-1,5-L-arabinanase for pectin releasing. Applied Biochemistry and Biotechnology. 2016 Nov, 180 (5): 900-916

6.Zhu Q#, Qian Y#, Yang Y, Wu W, Xie J*, Wei D. Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity. Journal of Food and Drug Analysis. 2016 Oct, 24 (4): 746-753

7.Du L, Brenner T, Xie J, Matsukawa S*. A study on phase separation behavior in kappa/iota carrageenan mixtures by micro DSC, rheological measurements and simulating water and cations migration between phases. Food Hydrocolloids. 2016, 55:81-88 

8.Zhao L, Lin J, Wang H, Xie J, Wei DZ*. Development of a two-step process for production of 3-hydroxypropionic acid from glycerol using Klebsiella pneumoniae and Gluconobacter oxydans. Bioprocess and Biosystems Engineering. 2015, 38 (12):2487-2495

9.Wang Y, Wang Y, Lang C, Wei D, Xu P, Xie J*. Genome Sequence of Lactobacillus curieae CCTCC M 2011381T, a Novel Producer of Gamma-aminobutyric Acid. Genome Announcements. 2015, 3(3):e00552-15

10.Yang Y, Zhang L, Guo M, Sun J, Matsukawa S, Xie J*, Wei D. Novel α-L-arabinofuranosidase from Cellulomonas fimi ATCC 484 and its substrate-specificity analysis with the aid of computer. Journal of Agricultural and Food chemistry. 2015, 63(14):3725-3733

11.Chen M, Lei X, Chen C, Zhang S, Xie J*, Wei D. Cloning, overexpression and characterization of a highly active endoinulinase gene from Aspergillus fumigatus CL1 for production of inulo-oligosaccharides. Applied Biochemistry and Biotechnology. 2015, 175(2):1153-1167

12.Fan J, Cui Y, Zhou Y, Wan M, Wang W, Xie J, Li Y*. The effect of nutrition pattern alteration on Chlorella pyrenoidosa growth, lipid biosynthesis-related gene transcription. Bioresource Technology. 2014, 164(1):214-220.

13.Liu Y, Zhang L, Guo M, Wu H, Xie J*, Wei D. Virtual screening for angiotensin I-converting enzyme inhibitory peptide from Phascolosoma esculenta. Bioresources and Bioprocessing. 2014, 1:17

14.Wang S, Yang Y, Zhang J, Sun J, Matsukawa S, Xie J*, Wei D. Characterization of abnZ2 (yxiA1) and abnZ3 (yxiA3) in Paenibacillus polymyxa, encoding two novel endo-1,5-α-L-arabinanases, AbnZ2 (YxiA1) and AbnZ3 (YxiA3). Bioresources and Bioprocessing. 2014, 1: 14

15.Wang S, Yang Y, Yang R, Zhang J, Chen M, Matsukawa S, Xie J*, Wei D. Cloning and characterization of a cold-adapted endo-1,5-α-L-arabinanase from Paenibacillus polymyxa and rational design for acidic applicability. Journal of Agricultural and Food chemistry. 2014, 62(33): 8460-8469

16.Wu H, Liu Y, Guo M, Xie J*, Jiang X*. A Virtual screening method for inhibitory peptides of angiotensin I converting enzyme. Journal of Food Science. 2014, 79(9): 1635-1642

17.WuY, LiuY, GuoM, LiP, DuL, FangM, WuH,XieJ*, WeiD. Nutritional composition and antihypertensive activity on spontaneously hypertensive rats of sipuncula Phascolosoma esculenta. Food and Function. 2014, 5 (9): 2317-2323

18.Li P, Jia J, Fang M, Zhang L, Guo M, Xie J*, Xia Y, Zhou L, Wei D. In vitro and in vivo ACE inhibitory of pistachio hydrolysates and in silico mechanism of identified peptide binding with ACE.Process Biochemistry. 2014, 49(5): 898-904

19.Li P, Jia J, Zhang D, Xie J*, Xu X, Wei D. In vitro and in vivo antioxidant activities of flavonoidfrom celery (Apium graveolens L. var. dulce). Food and Function. 2014, 5:50-56

20.Chen J, Yang R, Chen M, Wang S, Li P, Xia Y, Zhou L, Xie J*, Wei D. Production optimization and expression of pectin releasing enzyme from Aspergillus oryzae PO. Carbohydrate Polymers. 2014, 101:89-95

21.Zhou P, Zhang Y, Wang P, Xie J*, Ye Q.Butanol production from glycerol by recombinant Escherichia coli. Annuals of Microbiology. 2014, 64:219-227

授权专利

1、谢静莉，张龙，曹小飞，高允盛，赵丹，许学书. 一种含豆乳的奶酪及其制备方法. ZL 200810202514.X

2、张 晞，许学书，谢静莉，余东辉，夏月兰. 封闭式固体发酵反应装置. ZL 200910047129.7

3、谢静莉，张龙，许学书，高允盛，曹小飞，林炯.一种拉丝型混合干酪的制作方法及获得的混合干酪. ZL 200910051486.0

4、谢静莉，李晴辉，魏东芝. 一种涂抹型大豆干酪及其制作方法. ZL 201110358380.2

5、谢静莉，雷晓，孙贵朋，魏东芝. 一种食源性乳酸菌及其应用. ZL 201210044449.9

6、谢静莉，方明，李鹏，杜磊，吴燕玲，魏东芝. 降血压多肽. ZL 2013101240332

7、谢静莉，方明，张旭晟，邓高静，吴燕玲，王波，束雯婷，李莹，杜磊，李鹏. 莲子用于制备ACE抑制剂的应用. ZL 201210137731.1

联系方式：

电话：64251803 (O), 64252563 (Lab)

E-mail: jlxie@ecust.edu.cn