湖南师范大学

邓乐，男，理学博士，教授，博士生导师。

湖南师范大学生科院微生物系主任。1982年毕业于湖南师范大学获理学士学位; 1985年获武汉大学硕士学位。1996年获湖南大学理学博士学位;1998 — 2000年在美国印第安那大学和加州州立大学洛杉矶分校从事博士后研究工作; 2007.7— 2007.12在英国伦敦帝国理工学院访问学习。2002年被湖南省确定为学科带头人培养对象。先后主持国家863计划项目、国家自然科学基金项目等省部级课题二十多项。已在BIOSENS BIOELECTRON, APPL MICROBIOL BLOT, ENZYME MICROB TECH，BIORESOURCE TECHNOL等国内外重要学术刊物上发表论文80余篇, SCI他人引用1200余次。已培养博士硕士50多人。 

所在学科：湖南省微生物学重点学科

研究及招生方向：病原菌及分子诊断技术；纳米生物技术; 环境微生物技术

学术兼职: 湖南省微生物学学会副理事长，《生命科学研究》编委

教学：微生物学、 现代生物技术专题

获奖:

1.邓乐, 彭智辉, 李会东 (2009) 生物功能化磁性粒子的构建及其应用,湖南省自然科学奖二等奖

2. 丁兴华, 邓乐（指导教师）基于碳纳米管技术的快速检测病原菌方法的研究, 湖南省优秀硕士学位论文，2013

3.肖萧，邓乐（指导教师）高特异性免疫分子化磁性载体快速检测病原菌的研究，湖南省优秀硕士学位论文，2009

4.蒋军风，邓乐（指导教师）核壳结构水溶性量子点的合成与细菌检测应用的研究，湖南省优秀硕士学位论文，2011

5. 雷涵, 邓乐（指导教师） 微纳米生物功能磁性材料的构建及其在酶固定化中的应用, 湖南省优秀硕士学位论文，2005

6. 宁毅, 邓乐（指导教师）高特异性碳纳米生物传感器快速检测沙门氏菌的研究,湖南师范大学优秀博士学位论文，2015

近五年发表主要学术论文：

1. Keyi Liu, Xing Yan, Biyao Mao, Sheng Wang, Le Deng* Aptamer-based detection of Salmonella enteritidis using double signal amplification by Klenow fragment and dual fluorescence,Microchimica Acta,183:643–649, 2016 

2. Xing Yan，Wenkai Li，Keyi Liu，Le Deng* Highly sensitive fluorescent aptasensor for Salmonella paratyphi A via DNase I-mediated cyclic signal amplification, Analytical methods,7(24), 10243-10245,  2015 

3. Yi Ning, Lijuan Cheng, Min Ling, Xinru Feng, and Le Deng*Efficient suppression of biofilm formation by a nucleicacid aptamer, FEMS Pathogens and Disease, 73(6), 1-8, 2015 

4. Zhongjie Li,Yang Song, Wenhui Zhu and Le Deng*A terminal protectionsystem for the detection of adenosine triphosphate via enzyme-assisted signal amplification, Analytical Methods, 7, 970 - 975，2015 

5. Xinru Feng, Keyi Liu, Yi Ning, Lijuan Chen and Le Deng*A Label-free Aptasensor for Rapid Detection of H1N1 Virus based onGraphene Oxide and Polymerase-aided Signal Amplification，J Nanomed Nanotechnol, 6:3，1000288，2015 

6. Wenhui Zhu, Zhongjie Li, Xinxing Liu, Le Deng*，Determination of Shigella Flexneri by a NovelFluorescent Aptasensor, Anal letters, 48(18), 2870-2881,2015 

7. Min Ling, Zhihui Peng, Lijuan Cheng, Le Deng*Rapid Fluorescent Detection of Enterotoxigenic Escherichiacoli (ETEC) K88 Based on Graphene Oxide-DependentNanoquencher and Klenow Fragment-Triggered TargetCyclic Amplification, Applied Spectroscopy, 69(10):1175-1181,2015 

8.Yang Song , Wenkai Li , Yingfen Duan , Le Deng*Nicking enzyme-assisted biosensor for Salmonella enteritidis detection based on fluorescence resonance energy transfer. Biosensors & Bioelectronics, 55, 400-404, 2014 

9. Pingdao Mao, Yi Ning, Wenkai Li, Zhihui Peng,  Le Deng*Novel strategy combining SYBR Green I with carbon nanotubes for highly sensitive detection of Salmonella typhimurium DNA. Enzyme & Microbial Tech, 54: 15-19, 2014

10.  Yinfen Duan, Yi Ning, Yang Song,  Le Deng* Fluorescent aptasensor for the determination of Salmonella typhimurium based on a graphene oxide platform. Microchim Acta,  181(5): 647-653, 2014

11.  Yi Ning, WenKai Li, YingFen Duan, Ming Yang, Le Deng* High specific DNAzyme-aptamer sensor for Salmonella paratyphi A using single-walled nanotubes based dual fluorescence-spectrophotometric methods. J. Biomolecular Screening, 19: 1099-1106, 2014

12.  Yi Ning，Yingfen Duan，Yunyi Feng，Le Deng*Label-Free Fluorescent Aptasensor based on a Graphene Oxide Self-Assembled Probe for the Determination of Adenosine Triphosphate. Analytical Letters, 47(14), 2350-2360, 2014 

13.  Zhihui Peng, Min Ling, Yi Ning, Le Deng*Rapid Fluorescent Detection of Escherichia coli K88 Based on DNA Aptamer Library as Direct and Specific Reporter Combined With Immuno-Magnetic Separation.J of Fluorescence, 24(4):1159-1168, 2014 

14.  Yi Ning, Zhong Jie Li, Yin Fen Duan, Zhi Hui Peng and Le Deng*A novel biosensor for detection of S. typhimurium carrying SSeC gene based on the secondary qurnching effect of carbon nanotubes, Nanomaterials & Molecular Nanotech, 2: 5-9, 2013

15.  Ming Yang, Zhihui Peng, Yi Ning, Le Deng *(2013) Highly Specific and Cost-Efficient Detection of Salmonella Paratyphi A Combining Aptamers with Single-Walled Carbon Nanotubes. Sensors, 13, 6865-6881

16.  Guang Li, Fushuang Li, Le Deng * Increased yield of biotransformation of exemestane with β-cyclodextrin complexation technique, Steroids, 78(11): 1148-1151, 2013

17.  Qin Zhou, Yongzhe Chen, Ming Yang, Wenkai Li, Le Deng* Enhanced bioremediation of heavy metal from effluent by sulfate-reducing bacteria with copper-iron bimetallic particles support. Bioresource Technology, 136, 120-127, 2013 (IF5.039, 1区)

18.  Hui Chen, Dan Wang,Le Deng *Oligonucleotide-Based Fluorescence Probe for sensitive and selective detection of Ag(I) ions in Aqueous Solution. Water science & Technology, 85.3:444-458, 2012 

19.  Xinghua Ding, Hua Li, Le Deng* A novel homogenous detection method based on the self-assembled DNAzyme labeled DNA probes with SWNTs conjugates and its application in detecting pathogen [J] Biosensors & Bioelectronics, 26, 4596-4600，2011

20.  Dan Wang, Hui Chen, Hua Li,Le Deng*Detection of Staphylococcus aureus carrying the gene for toxic shock syndrome toxin 1 by quantum-dot-probe complexes，J of Fluorescence, 21:1525-1530, 2011 

21.  Fang Liu, Jiang Zhang, Rong Chen, Lingli Chen, Le Deng*  Highly Effective Colorimetric and Visual Detection of ATP by DNAzyme-Aptamer Sensor, Chemistry & Biodiversity, 8(2): 311-316, 2011 

22.  Hua Li, Xinghua Ding, Zhihui Peng, Le Deng*  Aptamer selection for the detection of Escherichia coli K88, Canadian journal of microbiology, 57:453-459，2011

23.  贺气志，陈辉，邓乐﹡ 混合硫酸盐还原菌与Cu/Fe颗粒协同处理含铬废水的研究, 环境科学, 32(7): 2000-2006，2011

24.  周明霞，陈勇喆，王辉，陈智，邓乐*发光细菌PB-P3.9的鉴定与gyrB、luxA基因系统发育分析, 食品科学, 32(15): 220-224，2011 

25.  JunFeng Jiang, ZhiHui Peng, Le Deng*Detection of Bifidobacterium Species-specific 16S rDNA Based on QD FRET Bioprobe. J of Fluorescence, 20(1): 356-369，2010 

26.Wenkai Li, Xinru Feng, Xing Yan, Keyi Liu, Le Deng*A DNA aptamer against influenza A virus: an effective inhibitor to the hemagglutinin-glycan interactions. Nucleic Acid Therapeutics, 2016 (in press) 

指导研究生情况：4名博士生、6名硕士生在读；50名硕士博士毕业；

联系方式：

Tel: 0731-88872927(O);

 Email：DengLe@Hunnu.edu.cn