湖南师范大学

湖南师范大学生命科学学院动物学研究生导师何善平介绍如下：

姓         名：何善平

职称职务：特聘教授、博士生导师、国家青年****入选者        

专    业：生理学

研究领域：动物分子营养与免疫

联系电话：0731-88872199/18670326886

电子邮箱：hesp@hunnu.edu.cn

通讯地址：湖南省长沙市麓山路36号湖南师范大学生命科学学院3号楼A224，邮编 410081

个人简介

北京大学理学博士，湖南师范大学“潇湘学者”特聘教授、博士生导师，国家青年****和湖南省百人计划（青年）入选者，第十二届湖南省政协委员。2002年获华中农业大学农学学士学位（动物医学专业），2011年获北京大学理学博士学位（生物技术专业）；2011年至2016年，在美国南加州大学Keck医学院分子微生物学与免疫学系从事博士后研究，研究肿瘤病毒调控天然免疫的分子机制。2016年作为海外高层次人才引进，加入印遇龙院士主持的动物营养与人体健康实验室，从事动物营养与免疫方面的研究。近年来，在Molecular Cell、PLoS Pathogens、Nucleic Acids Research等国际权威期刊发表高水平SCI论文10余篇，多次参加国际学术会议并做大会报告，参与翻译出版权威教材1部，获中国发明专利3项。目前主持国家青年****项目、湖南省百人计划项目、湖南省科技创新平台与人才计划（人才类）、潇湘学者特聘教授科研项目等4项人才计划项目。承担本科生《人体及动物生理实验》教学工作，指导本科生的国家级大学生创新性实验。 

研究兴趣

(1) 营养物质调控肠道天然免疫的分子机制

(2) 氨基酸感知、抗病毒天然免疫的翻译后修饰调控

代表性论文

(1) He S., Zhao J., Song S., He X., Minassian A., Zhou Y., Zhang J., Brulois K., Wang Y., Cabo J., Zandi E., Liang C., Jung J., Zhang X., Feng P. (2015) Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Molecular Cell 58, 134-146. (IF, 14.018) (在当期Molecular Cell作为研究亮点获得专评；Science Daily报道)

(2) Zhang J., He S., Wang Y., Brulois K., Lan K., Jung J., Feng P. (2015) Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase. PLoS Pathogens 11(3): e1004768. doi: 10.1371/journal.ppat.1004768. (IF, 8.057)

(3) Minassian A.#, Zhang J.#, He S., Zhao J., Zandi E., Saito T., Liang C., Feng P. An internally translated MAVS variant exposes its amino-terminal TRAF-binding motifs to deregulate interferon induction. PLoS Pathogens 11(7): e1005060. doi: 10.1371/journal.ppat.1005060. (#co-first author) (IF, 8.057)

(4) Zhao J., He S., Minassian A., Li J., Feng P. Recent advances on viral manipulation of NF-kappaB signaling pathway. Current Opinion in Virology 15, 103-111 (IF, 6.298)

(5) Zhang X., Wu Q., Cui S., Ren J., Qian W., Yang Y., He S., Chu J., Sun X., Yan C., Yu X., An C. (2015) Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. Journal of Experimental Botany 66, 2709-2721. (IF, 5.794)

(6) Zhang X., Wu Q., Ren J., Qian W., He S., Huang K., Yu X., Gao Y., Huang P., An C. (2012) Two Novel RING-type Ubiquitin Ligases, RGLG3 and RGLG4, Are Essential for Jasmonate-mediated Responses in Arabidopsis. Plant Physiology 160, 808-822. (IF, 7.394)

(7) He S., Tan G., Liu Q., Huang K., Ren J., Zhang X., Yu X., Huang P., and An C. (2011) The LSD1-Interacting Protein GILP Is a LITAF Domain Protein That Negatively Regulates Hypersensitive Cell Death in Arabidopsis. PLoS ONE 6(4): e18750. doi: 10.1371/journal.pone.0018750. (IF, 4.411)

(8) He S., Huang K., Zhang X., Yu X., Huang P., and An C. (2011) The LSD1-type Zinc Finger Motifs of Pisum sativa LSD1 Are a Novel Nuclear Localization Signal and Interact with Importin Alpha. PLoS ONE 6(7): e22131. doi: 10.1371/journal.pone.0022131. (IF, 4.411)

(9) Qian, W., Tan, G., He, S., Zhang, X., Zhang, X., Gao, Y., Liu, H., and An, C. (2007) Identification of a new AT-rich-element binding factor PsATF1 and its combined effect with PsGBF on the activation of PsCHS1 promoter. Frontiers in Bioscience 12, 1670-1679. (IF, 4.249)

(10) Qian, W., Tan, G., Liu, H., He, S., Gao, Y., and An, C. (2007) Identification of a bHLH-type G-box binding factor and its regulation activity with G-box and Box I elements of the PsCHS1 promoter. Plant Cell Reports 26, 85-93. (IF, 3.071)

(11) Tan, G., Gao, Y., Shi, M., Zhang, X., He, S., Chen, Z., and An, C. (2005) SiteFinding-PCR: a simple and efficient PCR method for chromosome walking. Nucleic Acids Research 33, e122. (IF, 9.112)