华中农业大学

个人概况：

周 洋，女

农学博士，硕士生导师，副教授；

水生动物医学系，水产学院，华中农业大学。

E-mail:  zhouyang@mail.hzau.edu.cn，zhouyang8728@gmail.com

通信：湖北省武汉市洪山区狮子山街1号，华中农业大学水产学院，邮编：430070

研究兴趣：

1.水生动物细菌性病原致病机制；

2.水生动物细菌性病原疫苗；

3.细菌耐药性机制。

教育背景：

2005/09-2009/07华中农业大学，生命科学技术学院，生物技术理科基地，学士

2012/05-2013/03 Montana State University-Department of Immunology and Infectious Diseases，联合培养博士生

2008/09-2013/06 华中农业大学，动物医学院，预防兽医专业，博士

工作经历：

2013/10-2015/10 华中农业大学，水产学院，博士后

2015/12-2017/05 University of Florida, Postdoctoral Associate

2015/10-至今     华中农业大学，水产学院，副教授

主持科研项目：

国家自然科学基金面上项目（31772889），嗜水气单胞菌CodRS双组份系统致病机制研究，2018/01-2021/12

国家自然科学基金青年项目（31402341），水气单胞菌分泌型核酸酶介导逃逸团头鲂中性粒细胞胞外网捕杀的机制研究，2015/01-2017/12

中国博士后科学基金特别资助（2015T80819），团头鲂巨噬细胞胞外网性质研究，2015/09-2018/08

华中农业大学自主科技创新基金（2662016QD010），鲤科鱼类巨噬细胞胞外网研究，2016/01-2019/01

代表性论文：

1. Yang Zhou#, Xingxing Dong#, Zhiwei Li#, Geng Zou, Li Lin, Xiaohong Wang, Huanchun Chen, Robin B. Gasser, Jinquan Li*. Predominance of Streptococcus suis ST1 and ST7 in human cases in China, and detection of a novel sequence type, ST658. Virulence,2017, 8(6):1031-1035. (IF=5.418，JCR 一区)

2. Yachan Ji, Jinquan Li, Zhendong Qin, Aihua Li, Zemao Gu, Xiaoling Liu, Li Lin, Yang Zhou*. Contribution of nuclease to the pathogenesis of Aeromonas hydrophila. Virulence, 2015, 6(5): 515-22 (IF=5.418，JCR 一区)

3. Feifei Zheng, Muhammad Asim, Jiangfeng Lan, Lijuan Zhao, Shun Wei, Nan Chen, Xiaoling Liu, Yang Zhou*, Li Lin*. Molecular Cloning and Functional Characterization of Mannose Receptor in Zebra Fish (Danio rerio) during Infection with Aeromonas sobria. Int J Mol Sci, 2015, 16(5): 10997-1012 (IF= 3.257)

4. Yang Zhou#, Yan Wang#, Limei Deng, Chengkun Zheng, Fangyan Yuan, Huanchun Chen, Weicheng Bei, Jinquan Li*. Evaluation of the protective efficacy of four novel identified membrane associated proteins of Streptococcus suis serotype 2. Vaccine, 2015, 33(19): 2254-60 （IF= 3.624 JCR一区）

5. Xiaoling Liu, Xiaocheng Tang, Li Wang, Jie Li, Hong Wang, Shun Wei, Rui Fang, Wei Ji, Gailing Yuan, Nan Chen, Zemao Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, Yang Zhou*, Li Lin*. Molecular cloning and expression analysis of mannose receptor in blunt snout bream (Megalobrama amblycephala). Molecular Biology Reports, 2014, 41(7): 4601-11 (IF= 2.024)

6 Yang Zhou, Tracey S Hanks, Wenchao Feng, Jinquan Li, Guanghui Liu, Mengyao Liu, Benfang Lei*, The sagA/pel locus does not regulate the expression of the M protein of the M1T1 lineage of group A Streptococcus, Virulence, 2013, 4(8): 698-706  (IF=5.418 JCR 一区)

7. Yang Zhou, Lu Li, Zhaohui Chen, Hong Yuan, Huanchun Chen, Rui Zhou*, Adhesion protein ApfA of Actinobacillus pleuropneumoniae is required for pathogenesis and is a potential target for vaccine development, Clin Vaccine Immunol, 2013, 20(2): 287-94  (IF= 2.425)

8. Xingxing Dong, Zhendong Qin, Xianqin Hu, Jiangfeng Lan, Gailing Yuan, Muhammad Asim, Yang Zhou, Taoshan Ai, Jie Mei, Li Lin*. Molecular cloning and functional characterization of cyclophilin A in yellow catfish (Pelteobagrus fulvidraco). Fish Shellfish Immunol, 2015, 45(2): 422-430

9. Wenwen Wang, Muhammad Asim, Lizhu Yi, Abeer M. Hegazy, Xianqin Hu, Yang Zhou, Taoshan Ai, Li Lin*. Abortive infection of snakehead fish vesiculovirus in ZF4 cells was associated with the RLRs pathway activation by viral replicative intermediates. Int J Mol Sci, 2015, 16(3):6235-50

10. Xiaoheng Zhao, Lichun Liu, Abeer M. Hegazy, Hong Wang, Jie Li, Feifei Zheng, Yang Zhou, Weimin Wang, Jun Li, Xiaoling Liu*, Li Lin*. Mannose receptor mediated phagocytosis of bacteria in macrophages of blunt snout bream (Megalobrama amblycephala) in a Ca2+-dependent manner. Fish and Shellfish Immunology, 2015, 43(2): 357-63

11. Liyue Liu, Bibo Zhu, Shusheng Wu, Li Lin, Guangxin Liu, Yang Zhou, Weimin Wang, Muhammad Asim, Junfa Yuan, Lijuan Li, Min Wang, Yuannan Lu, Huanling Wang, Jianbo Cao, Xueqin Liu*. Spring Viremia of Carp Virus Induces Autophagy for Necessary Viral Replication. Cell Microbiol, 2015, 17(4): 595-605

12. Weidong Zhou, Yulei Zhang, Yi Wen, Wei Ji, Yang Zhou, Yachan Ji, Xiaoling Liu, Weimin Wang, Muhammad Asim, Xufang Liang*, Taoshan Ai*, Li Lin*. Analysis of the transcriptomic profilings of Mandarin fish (Siniperca chuatsi) infected with Flavobacterium columnare with an emphasis on immune responses. Fish and Shellfish Immunology, 2015, 43(1): 111-9

13.Wenjun Xu, Zhendong Qin, Hui Shi, Jiangfeng Nan, Yang Zhou, Xiaoling Liu, Jianjun Xie, Genshen Wang, Weimin Wang, Muhammad Asim, Lingbing Zeng, Li Lin*. Mass mortality associated with a viral-induced anaemia in cage-reared large yellow croaker, Larimichthys crocea (Richardson). Journal of Fish Diseases, 2015, 38(5): 499-502

14. Xiaodan Liu, Jiannan Huang, Shaoping Weng, Xiaoqin Hu, Wenjie Chen, Zhendong Qin, Xingxing Dong, Xiaoling Liu, Yang Zhou, Muhammad Asim, Weimin Wang, Jianguo He, Li Lin*. Infections of nervous necrosis virus in wild and cage-reared marine fish from South China Sea with unexpected wide host ranges. J Fish Dis, 2015, 38(6): 533-40

15. Lichun Liu, Yang Zhou, Xiaoheng Zhao, Hong Wang, Li Wang, Gailing Yuan, Muhammad Asim, Weimin Wang, Lingbing Zeng, Xiaoling Liu, Li Lin. Oligochitosan stimulated phagocytic activity of macrophages from blunt snout bream (Megalobrama amblycephala) associated with respiratory burst coupled with nitric oxide production. Dev Comp Immunol, 2014, 47(1): 17-24

16. Jinquan Li, Guanghui Liu, Wenchao Feng, Yang Zhou, Mengyao Liu, James A. Wiley, Benfang Lei*, Neutrophils select hypervirulent CovRS mutants of M1T1 group A Streptococcus during subcutaneous infection of mice, Infect Immun, 2014, 82(4): 1579-90

17. Li Wang, Lichun Liu, Yang Zhou, Xiaoheng Zhao, Mingjun Xi, Shun Wei, Rui Fang, Wei Ji, Nan Chen, Zemao Gu, Xueqin Liu, Weimin Wang, Muhammad Asim, X Liu*, L Lin*, Molecular cloning and expression analysis of mannose receptor C type 1 in grass carp (Ctenopharyngodonidella), Dev Comp Immunol, 2014, 43(1): 54-8

18. Jinquan Li, Hui Zhu, Wenchao Feng, Mengyao Liu, Yingli Song, Xiaolan Zhang, Yang Zhou, Weicheng Bei, Benfang Lei*, Regulation of inhibition of neutrophil infiltration by two-component regulatory system CovRS in subcutaneous mouse infection with Group A Streptococcus, Infect Immun, 2013, 81(3): 974-83

19. Lu Li, Zhuofei Xu, Yang Zhou, Lili Sun, Ziduo Liu, Huanchun Chen, Rui Zhou*,Global effects of catecholamines on Actinobacillus pleuropneumoniae gene expression, PLoS ONE, 2012, 7(2): e31121

20. Jinquan Li, Jin Xia, Chen Tan, Yang Zhou, Yan Wang, Chengkun Zheng, Huanchun Chen, Weicheng Bei*, Evaluation of the immunogenicity and the protective efficacy of a novel identified immunogenic protein, SsPepO, of Streptococcus suis serotype 2, Vaccine, 2011, 29(38): 6514-9

21. Lu Li, Zhuofei Xu, Yang Zhou, Tingting Li, Lili Sun, Huanchun Chen, Rui Zhou*, Analysis on Actinobacillus pleuropneumoniae LuxS regulated genes reveals pleiotropic roles of LuxS/AI-2 on biofilm formation, adhesion ability and iron metabolism, Microb Pathogenesis, 2011, 50(6): 293-302

22. Jinquan Li, Chen Tan, Yang Zhou, Shulin Fu, Linlin Hu, Jin Hu, Huanchun Chen, Weicheng Bei*, The two-component regulatory system CiaRH contributes to the virulence of Streptococcus suis 2,Vet Microbiol, 2011, 148(1): 99-104