中国药科大学

杨蕾，女，博士，1980年5月生，中国药科大学天然药物化学教研室副教授。主要承担本科生天然药物化学课程、研究生天然物结构化学课程的教学工作。2003年中国药科大学生物技术专业本科毕业。2008年中国药科大学微生物与生化药学博士毕业，导师吴梧桐教授。2011年中国药科大学中药学院博士后出站，导师孔令义教授。主要研究方向为天然产物的高通量药物筛选体系的建立、中药及天然药物的活性成分和机制研究、基于生物酶反应的生物转化研究。具体内容包括抗肿瘤药物的筛选和机制研究、逆转肿瘤多药耐药性的药物筛选和机制研究等。

联系方式：Tel：025-83271402,Email：dorothy19802003@163.com

通信地址：南京市童家巷24号，中国药科大学天然药物化学教研室，邮编210009。

主持的科研项目:

中国药科大学引进人才基金

2011-2012中央高校基本科研业务费培育项目（P-gp高表达骨肉瘤多药耐药细胞模型的建立及中药中相关新型逆转剂的筛选，项目批准号：JKP2011014，8万）

2013-2015国家自然科学基金（逆转P-gp介导的骨肉瘤细胞多药耐药性作用中药的筛选及其机制研究，项目批准号：81202901，22万）

近期代表性论文：

Geng, Y.D., Yang, L. (Co-first author), Zhang, C., Kong, L.Y. 2014. Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells. Food Chem. Toxicol. 73. 7-16.

Hu, S.M., Luo, J., Yang, L. (co-corresponding author), Kong, L.Y. 2014.Exploration of possible biosynthetic origin of 1/8/9-orthoester moiety in phragmalins. Tetrahedron Letters. 55, 815-817.

Wu, L., Luo, J., Zhang, Y., Wang, X., Yang, L. (co-corresponding author), Kong, L.Y. 2014. Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc. Fitoterapia. 93, 201-208.

Zhang, C., Yang, L., Wang, X.B., Wang, J.S., Geng, Y.D., Yang, C.S., Kong, L.Y. 2013. Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells. Cancer Lett. 340, 51-62.

Guo, C., Wang, J.S., Zhang, Y., Yang, L., Wang, P.R., Kong L.Y. 2012. Relationship of chemical structure to in vitro anti-inflammatory activity of tirucallane triterpenoids from the stem barks of Aphanamixis grandifolia. Chem Pharm Bull. 60, 1003-1010.

Yang, L., Wei, D.D., Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine. 18, 710-718.

Yang, L., Wei, D.D, Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal effects of traditional Chinese herbs on multidrug resistance in cancer cells. Nat Prod Res. 25, 1885-1889.

Yang, L., Jiang, C., Liu, F., You, Q.D., Wu, W.T. 2008. Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor. Biol Pharm Bull. 31, 1397-1402.

Jiang, C., Yang, L. (Co-first author), Wu, W.T., Guo, Q.L., You, Q.D. 2011. CPUYJ039, a newly synthesized benzimidazole-based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity. J Pharm Pharmacol. 63, 1462-1469.

Jiang, C., Yang, L., Wu, W.T., Guo, Q.L., You, Q.D. 2011. De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. Bioorg Med Chem. 19, 5612-5627.

Fu, R.G., You, Q.D., Yang, L., Wu, W.T., Jiang, C., Xu, X.L. 2010. Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. Bioorg Med Chem. 18, 8035-8043.

Liu, F., Yu, L.Q., Jiang, C., Yang, L., Wu, W.T., You, Q.D. 2010. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. Bioorg Med Chem. 18, 4167-4177.

Jiang, C., You, Q., Liu, F., Wu, W., Guo, Q., Chern, J., Yang, L., Chen, M. 2009. Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors. Chem Pharm Bull. 57, 567-71.

杨蕾，江程，刘飞，尤启冬，吴梧桐*。Eg5抑制剂体外高通量筛选。药物生物技术。2008；15（6）：418－424。